Evidence-based practice, which is a problem-solving approach to how healthcare professionals provide care, is based on studies and data about care of the patient with clinical skills and patient preferences and values. It provides a scientific approach that helps nurses provide quality care to a particular population. Evidence-based practice has gained energy in nursing. It offers opportunities for more individualized nursing care. It also offers opportunities for nursing to broaden its dynamism and make better use of clinical judgment. Evidence-based practice is an important method that nurses can use to provide excellent care to patients and their relatives. Research has shown that nurses who treat their patients using an evidence-based practice method tend to provide better care than nurses who do not. Evidence-based practice includes a methodological approach to the most meaningful evidence that comes with the clinical solution. . It provides the nurse with the method to approach the patient by focusing on health problems and well-being. The evidence-based practice method helps nurses provide better care that ensures patient safety and monitors effectiveness. When patient care is not adequately provided with applied evidence it can cause physical and emotional harm not only to the patient but also to the entire family and relatives. When people are sick, in most cases they are hopeless and dependent on those who have the best skills to advocate for the best healthcare for them. The evidence-based practice method allows nurses to fulfill their role and meet their job criteria by improving their knowledge and skills to achieve better outcomes. It has many benefits for the patient. For example, it reduces the amount of time spent on practice-based practice for the benefit of patients. There has been a lot of research in several specific areas that need to be incorporated into evidence-based practice. Therefore, it is important for nurses to update their knowledge in validating new research by providing better care for excellent outcomes. Nurses in Macedonia have found much success putting into practice updated knowledge on evidence-based practice which improves their clinical performance, therefore they have experienced a significant drop in mortality from several health problems. Nurses must understand that developing a research-strengthened evidence base is critical before reaching any conclusions about any specific practice. Implementation must be applied to improve outcomes that are meaningful to contributors and that are measured against formulated objectives.