Topic > Tanning Salon Case Study - 1144

Cancer is a disease characterized by uncontrolled cell growth. a) In 2-3 sentences, describe the difference between proto-oncogenes and tumor suppressor genes.b) Find an example of a tumor suppressor gene (not Rb or VHL). In 2-3 sentences, explain its function and describe a cancer with which it is associated.a) Proto-oncogenes are normal growth genes that can lead to cancer if they mutate or make too many copies. Proto-oncogenes are oncogenes that function normally, but transform/mutate into an oncogene (e.g., by overexpression) which is a cell with a loss of growth control thus causing cancer. A tumor suppressor gene codes for proteins that inhibit or stop cell growth (and also repair DNA and program cells to die) which, if mutated, can cause uncontrolled growth leading to cancer. b) FasR, FAS receptor is a tumor suppressor gene located on chromosome 8 in humans. FasR programs cells to induce cell death. It has been shown that low expression of FasR in lung cancer tumor cells correlates with a worse prognosis because cancerous tumor cells do not receive as many signals to die, so growth among cancerous cells is more rapid (Sathiah et al,