The less specific nature of PRRs is crucial to the immediate role of the innate immune system that allows them to respond to a wide range of pathogens. In line with their role, innate immune cells are found dispersed throughout the body (Mogensen, 2009). Instead, T and B cells will gather in the lymph nodes until they are activated. As I mentioned previously, finding a T or B cell with a specific antigen-binding ability is rare, so once a specific lymphocyte has been activated by an antigen, it must undergo clonal expansion to ensure that there is a sufficient amount of that specific cell to neutralize the pathogen. and this process takes a few days. Therefore the number and effectiveness of specific TCRs and BCRs fluctuate over time (Kindt, et al.,