Pancreas transplant is an established therapy for patients with type 1 diabetes mellitus. Discuss the evidence, advantages and disadvantages, and outcomes of pancreas transplant. What other developments are related to beta cell transplantation and what are the difficulties? IntroductionPancreas transplant is a surgical procedure in which a diseased pancreas is replaced with a healthy one in patients with type 1 diabetes allowing the production of insulin, which they may not produce endogenously. Pancreas transplant is commonly combined with kidney transplant which has been shown to reduce complications of type 1 diabetes. Pancreas transplant holds patients' key to insulin independence, which in turn leads to improved quality of life with fewer complications of diabetes, showed positive results of 76% with well-functioning pancreas one year later. The procedure is known to be quite popular (1), it has been estimated that over 300 people in the UK are on the transplant waiting list (1). Ever since the success of early pancreas transplant, people are looking forward to that operation to solve their diabetes problems. The first pancreas transplant was performed in 1966, at the University of Minnesota Medical Center, by a team, Dr. Kelly, Dr. Lillehei, Dr. Merkel, Dr. Idezuki Y and Dr. Goetz, who transplanted a kidney, a duodenum and a pancreas in the body of a 28-year-old woman, immediately after the transplant, her blood sugar levels decreased, and unfortunately she died three months later due to pulmonary embolism. In 1979, at the same center, David ER Sutherland, MD, PhD, performed the world's first successful partial pancreas transplant. The University of Minnesota Medical... middle of paper... and tumors. (----------- )Islet transplantation is a rapidly evolving technology with advantages and disadvantages, which is why it should only be performed in controlled research studies.Conclusion: -Pancreas transplantation it is the key for patients to insulin independence leading to a better quality of life, with fewer diabetic complications. Pancreatic islet cell transplantation is another intervention for the permanent management of uncontrolled and complicated type I DM, especially hypo. The indications and contraindications for pancreas transplant and islet cell transplant depend on the type of transplant the patient needs. The results of pancreas transplantation and islet cell transplantation are promising. Further developments in this field are coming in the hope of finding an effective and efficient solution for type 1 DM and its complications.