One Hundred Years of Solitude has numerous themes throughout the book. Gabriel Garcia Márquez tells how the city of Macondo was born from its foundation to its disappearance. The main theme that Gabriel carried throughout the book was the different forms of loneliness. Macondo has experienced many events that simply led to the fall of the city, one of them being the catastrophic events that happened. The catastrophic events that happen in Macondo are the tools used for loneliness. There are at least three plagues that have struck Macondo, the plague of insomnia and the rain. The plague of insomnia is when you lose your memory and can't sleep. The second is when it rains for almost five years in Macondo. The third is the wind where it destroys the city at the end of the novel. This article will explain how these three plagues led to the fall of Macondo and why they represent Gabriel's main theme in Solitude. The first plague is the plague of insomnia which was introduced to Macondo by Rebecca who came to Jose as an orphan. The plague of insomnia can be spread simply by being around the person infecting it. The plague is like a common cold that can be contracted by being near the infected person. When the Indian women saw her not sleeping and saw that Rebecca had cat-like symptoms, such as her eyes lighting up at night, she became afraid and left the house the next morning. The other Indian stayed behind because she knew there was no escape from the plague. From what Márquez says: “His sister stayed because her fatalistic belief says that once she enters a house no one can escape the plague” (44). Even if you leave the house the next morning, there is still a possibility that the person will be infected with the plague. That line... in the middle of the paper......, Márquez is a brilliant writer who takes certain events from different elements and inserts them into his book. The overall main theme is loneliness which runs throughout the book. Márquez uses a sequence of events such as plagues in which he represents a different form of loneliness. Whether it's memory loss where not knowing anyone makes you isolated, like Rebecca when she was first introduced. The second is the rain that did not stop for almost five years after the soldiers' massacre of the workers. The rain is a form of loneliness because the people within the city could not connect to the outside world and as such were isolated. These events caused the scrolls to happen when Aurelian deciphered the scrolls thus enacting one hundred years of solitude as not only was the city wiped out, but he no longer had any descendants, so he was forever alone..