Topic > Animal Cell Essay - 1650

A cell functions properly only when all its organelles are healthy and functional. Therefore, when an organelle malfunctions, the cell will no longer be able to perform its tasks as best as possible. Furthermore, the organism (animal or human) can suffer from diseases and side effects due to the malfunctioning of cellular organelles. For example, when the mitochondria of human cells do not function at their best or malfunction, the individual may suffer from a disease such as Leigh syndrome. As previously mentioned, mitochondria are the “powerhouse” of the cell, meaning they produce the energy necessary for the cell to function properly, as well as to carry out active transport. Therefore, when a mutation occurs in mitochondrial DNA, the human body lacks the energy needed to carry out any activity, which ultimately results in the aforementioned Leigh syndrome. Leigh syndrome is often identified as the disease that causes several blackouts, including fatal ones, loss of mental and motor skills and many other side effects such as diarrhea, vomiting and eating problems ("mitochondrial disease"). This syndrome is not very common, in fact it affects only one newborn in 40,000 (“Leigh syndrome”). More specifically, mitochondria “use oxygen to convert energy from food” into a form useful to the cell (“Leigh syndrome”). During mitochondrial energy production (ATP), five protein complexes pass through and obtain the necessary amount of ATP through a transfer of electrons. However, when these complexes traverse the mitochondria, mutations in the mitochondrial DNA fail to transfer the electrons necessary for the assembly of the complexes, which then results in the production of non-functional complexes that eventually become Leigh complexes.