Atherosclerosis is a cardiovascular disease characterized by the deposition of materials such as lipids, cholesterol, and proteins such as fibrins in the arteries, as shown in Figure 1 below. This leads to increased resistance to blood flow and causes increased stress on the heart. The main risk of atherosclerosis is that it greatly increases the chance of blood clots forming in the arteries. If such clots occur in the carotid or coronary arteries, they can cause strokes or myocardial infarctions, which can be fatal2. This article seeks to analyze how physical principles can be used to elucidate the pathophysiology of atherosclerosis and its effects on the human body. Physical Principles Continuity Equation This equation states that for an incompressible, inviscid fluid with constant density flowing through a channel, the mass and volume of the fluid are conserved. Consequently, the fluid volume flow rate must be constant at different points where the cross-sectional area differs. ∆V/∆T=A_1 V_1= A_2 V_2 (1)With reference to Eq. (1), ∆V/∆T refers to the fluid volume flow rate, while A refers to the cross-sectional area and V to the fluid velocity at points 1 and 2 in a pipe, respectively. From Eq. (1), it can be seen that, since the volumetric flow rate of the fluid is assumed to be constant for an incompressible fluid, a decrease in the cross-sectional area of ​​a pipe would lead to an increase in the velocity of the fluid passing through it3. Bernoulli equationIdeally, in the absence of fluid friction, the flow of incompressible fluids can be described by the Bernoulli equation:P_1+ ρgy_1+1/2 ρv_1^(2 )= P_2+ ρgy_2+1/2 ρv_2^(2 ) (2 )With reference to eq. (...... half of the article ...... lp to reduce low-density lipoprotein levels and potentially slow the development of atherosclerotic plaques in blood vessels16. With these advances in the pharmaceutical field, it could be much easier to control the progression of atherosclerosis in the future. Works cited1. Merck - MK-0524B - Treatment of atherosclerosis (6 June 2014). Singer, based on the work of P. Raven and G. Johnson, Biology, 8th ed., (McGraw-Hill Education (Asia), Singapore, 2008), pp. 994-995.3, H. Young and R. Geller, Sears & Zemansky's College Physics, 8th edition, (Pearson Education Inc., San Francisco, 2007), pp. 422-426, 428, 430-.431.4 P. Davidovits, Physics in biology and medicine, 3rd ed., (Elsevier Inc. , United States of America, 2008), pp. 101-104, 110-112.